リコンビナント抗体、組換え抗体は、DNA断片を細菌、酵母、動物細胞に挿入する組換えDNA技術を使用して作製された抗体ですが、得られる組換え生物は、それが異なる種由来であっても抗体を発現し、それらの組換え抗体はさまざまな研究に使用することができます。さまざまな疾患の治療に用いる医薬品の調製においての使用も可能です。バイオロジカがお届けするCreative Biolabs社のFab Fragment Antibodyのご紹介です。

Advantages of Recombinant Antibodies:

High affinity
Wide applications
Isotype switching possible
Reproducibility, speed, decreased time to produce rAb
No animals required
Conditional control

Fab Fragment Antibodies

*価格等はお気軽にお問い合わせください。

Creative Biolabs社は、Fab断片(Fab fragment)の抗体生産の専門会社です。Fabフラグメントは、VH、CH1、VLおよびCL1の4つのドメインからなる特別な抗体です。440から450個のアミノ酸を有し、その分子量は約47～48kDaです。抗体全体と比較して、Fab断片にはいくつか利点がありますが、一方では、組織に浸透しやすく、大腸菌などのより単純な発現系によって生成することができ、一方では、Fab断片はFc領域を欠くので、Fc部分とFc受容体との間の相互作用が除去されます。したがって、Fabフラグメントは、抗体特異性を増強し、エフェクター機能を低下させるのです。Fabフラグメント抗体は、ますます重要になってゆきます。現在、Abciximab (ReoPro®)、ranibizumab (Lucentis®)およびcertolizumab pegol (Cimzia®)の3つのFabフラグメント抗体が市販されております。Creative Biolabsの科学者も、お客様のご要求にお応えするべく、より多くのFabフラグメント抗体を生産するために懸命に取り組んでいます。

ピックアップ -Hot Products-

Recombinant Anti-Human IFNA1 Antibody Fab Fragment
Cat: MOM-H62-F(P)
Abbr: Recombinant Anti-IFNA1 MAb Fab
Size: 1 mg
Recombinant Anti-Human mstn Antibody Fab Fragment
Cat: MOM-18593-F(E)
Abbr: Anti-mstn Antibody Fab
Size: 1 mg
Recombinant Anti-Human tnni1 Antibody Fab Fragment
Cat: MOM-18517-F(E)
Abbr: Anti-tnni1 Antibody Fab
Size: 1 mg
Recombinant Anti-Human tnfrsf6b Antibody Fab Fragment
Cat: MOM-18511-F(P)
Abbr: Anti-tnfrsf6b Antibody Fab
Size: 1 mg
Recombinant Anti-Human cspg4 Antibody Fab Fragment
Cat: MOM-18380-F(E)
Abbr: Anti-cspg4 Antibody Fab
Size: 1 mg
Recombinant Anti-Human LTA Antibody Fab Fragment
Cat: MOM-18071-F(P)
Abbr: Anti-LTA Antibody Fab
Size: 1 mg
Recombinant Anti-Human ctag1b Antibody Fab Fragment
Cat: MOM-18453-F(P)
Abbr: Anti-ctag1b Antibody Fab
Size: 1 mg
Recombinant Anti-Human ereg Antibody Fab Fragment
Cat: MOM-18356-F(E)
Abbr: Anti-ereg Antibody Fab
Size: 1 mg

詳細

Cat：MOM-H62-F(P)
- Product Overview: Recombinant human Antibody Fab Fragment is directed against Human IFNA1, expressed in E. coli
- Target: IFNA1
- Type: human Fab-IgG1 - kappa
- Species Reactivity: Human
- Expression Host: E. coli
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: IFNA1 (interferon alpha 1, IFN-alpha, IFN alpha 1/13, IFN 13) [Homo sapiens]
- Purity: >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Purification: Purified by Nickel ion affinity chromatography
- Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
- Antigen Description: This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot,
- Gene ID: 3439
- Synonyms: IFNA1; interferon, alpha 1; interferon alpha-1/13; IFL; IFN; IFN ALPHA; IFN alpha 1b; IFN alphaD; IFNA13; IFNA@; interferon alpha 1b; leIF D; IFN-alpha 1b; IFN-alpha-1/13; interferon-alpha1; interferon alpha-D; IFN-ALPHA; IFN-alphaD; MGC138207; MGC138505; MGC138507;
- Download Datasheet: ダウンロード

Cat：MOM-18593-F(E)
- Product Overview: Recombinant Mouse Antibody Fab Fragment is bind to Human MSTN, expressed in Chinese Hamster Ovary cells(CHO)
- Target: MSTN
- Type: Fab
- Immunogen: The details of the immunogen for this antibody are not available.
- Species Reactivity: Human
- Expression Host: CHO
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: Tested positive against native antigen.
- Purity: Purity >95% by SDS-PAGE.
- Storage: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
- Antigen Description: Acts specifically as a negative regulator of skeletal muscle growth.
- Function: cytokine activity; growth factor activity; receptor binding; contributes_to receptor binding;
- Gene ID: 2660
- Synonyms: MSTN; myostatin; GDF8, growth differentiation factor 8; growth/differentiation factor 8; GDF-8; growth differentiation factor 8; GDF8; MSLHP;
- Download Datasheet: ダウンロード

Cat: MOM-18517-F(E)
- Product Overview: Recombinant Mouse Antibody Fab Fragment specifically binds to Human TNNI1, expressed in Chinese Hamster Ovary cells(CHO)
- Target: TNNI1
- Type: Fab
- Species Reactivity: Human
- Expression Host: CHO
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: Tested positive against native antigen.
- Purity: >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage: 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
- Antigen Description: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
- Function: actin binding; tropomyosin binding;
- Gene ID: 7135
- Synonyms: TNNI1; troponin I type 1 (skeletal, slow); troponin I, skeletal, slow; troponin I, slow skeletal muscle; troponin I, slow-twitch isoform; TNN1; SSTNI; DKFZp451O223
- Download Datasheet: download

Cat: MOM-18511-F(P)
- Product Overview: Recombinant Mouse Antibody Fab Fragment is specific to Human TNFRSF6B, expressed in E. coli
- Target: TNFRSF6B
- Type: Fab
- Immunogen: Recombinant fragment, corresponding to amino acids 32-142 of Human DcR3
- Species Reactivity: Human
- Expression Host: E. coli
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: Tested positive against native antigen.
- Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage: 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
- Antigen Description: Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis.
- Function: protein binding; receptor activity;
- Gene ID: 8771
- Synonyms: TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy; tumor necrosis factor receptor superfamily member 6B; DcR3; DCR3; M68; TR6; decoy receptor 3; decoy receptor for Fas ligand; M68E; DJ583P15.1.1
- Download Datasheet: download

Cat: MOM-18380-F(E)
- Product Overview: Recombinant Mouse Antibody Fab Fragment specifically binds to Human CSPG4, expressed in Chinese Hamster Ovary cells(CHO)
- Target: CSPG4
- Type: Fab
- Immunogen: Cell extract of HEK293 cells expressing the D3 domain of rat NG2, corresponding to amino acids 1592-2222.
- Species Reactivity: Human
- Expression Host: CHO
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: Tested positive against native antigen.
- Purity: >95.0% as determined by analysis by RP-HPLC.
- Storage: At -20°C for one year.
Background
- Antigen Description: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
- Function: collagen binding; protein kinase binding; signal transducer activity;
- Gene ID: 1464
- Synonyms: CSPG4; chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma associated); HMW MAA; MCSP; MCSPG; MEL CSPG; melanoma associated chondroitin sulfate proteoglycan; MSK16; NG2; chondroitin sulfate proteoglycan NG2; melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4 (melanoma-associated); HMW-MAA; MEL-CSPG
- Download Datasheet: download

Cat: MOM-18071-F(P)
- Product Overview: Recombinant Humanized (from mouse) Antibody Fab Fragment is bind to Human TNF beta, expressed in E. coli
- Target: TNF beta
- Type: Fab Fragment based on Humanized (from mouse) IgG1 - kappa
- Immunogen: The details of the immunogen for this antibody are not available.
- Species Reactivity: Human
- Expression Host: E. coli
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: Tested positive against native antigen.
- Purity: Purity >95% by SDS-PAGE.
- Storage: At -20°C for one year.
Background
- Antigen Description: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
- Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding;
- Gene ID: 4049
- Keywords: 0
- Synonyms: LTA; lymphotoxin alpha (TNF superfamily, member 1); TNFB; lymphotoxin-alpha; LT; TNFSF1; LT-alpha; TNF-beta; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1;
- Download Datasheet: download

Cat: MOM-18453-F(P)
- Product Overview: Recombinant Mouse Antibody Fab Fragment binds selectively to Human Ctagged1B, expressed in E. coli
- Target: Ctagged1B
- Type: Fab
- Immunogen: 293T cell transfected with Human Ctagged1B expression vector.
- Species Reactivity: Human
- Expression Host: E. coli
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: Tested positive against native antigen.
- Purity: >95.0% as determined by analysis by RP-HPLC.
- Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
- Antigen Description: Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).
- Gene ID: 1485
- Synonyms: Ctagged1B; cancer/testis antigen 1B; cancer/testis antigen 1 , Ctagged, Ctagged1; cancer/testis antigen 1; CT6.1; ESO1; LAGE2A; LAGE2B; NY ESO 1; cancer antigen 3; cancer/testis antigen 6.1; l antigen family member 2; New York esophageal squamous cell carcinoma 1; autoimmunogenic cancer/testis antigen NY-ESO-1; Ctagged; Ctagged1; Ctagged1A; LAGE-2; NY-ESO-1
- Download Datasheet: download

Cat: MOM-18356-F(E)
- Product Overview: Recombinant Mouse Antibody Fab Fragment specifically binds to Human EREG, expressed in Chinese Hamster Ovary cells(CHO)
- Target: EREG
- Type: Fab
- Species Reactivity: Human
- Expression Host: CHO
- Applications: Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
- Specificity: Tested positive against native antigen.
- Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage: At -20°C for one year.
Background
- Antigen Description: May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.
- Function: epidermal growth factor receptor binding; epidermal growth factor receptor binding; growth factor activity; protein binding;
- Gene ID: 2069
- Synonyms: EREG; epiregulin; proepiregulin; ER
- Download Datasheet: download